Programme

The CSSB Opening Symposium will explore new frontiers in structural systems biology with a particular focus on host – pathogen interactions. The symposium will take place from 13-15 November 2017 in Hamburg, Germany. The preliminary programme for the symposium can be found below.

Day 1: November 13, 2017
10:30 - Registration
11:30 - Life Science Opportunities on the Bahrenfeld Campus: An open session

 

Welcome Address / Key Note Lecture
Time: Speakers:
13:10 Welcome Address
Kay Grünewald
13:15 CSSB in a nutshell
Matthias Wilmanns
13:25 Welcome Address
Joachim Herz Stiftung

 

Session 1A: “Integrating and merging structural with complementary data across multiple scales and dimensions”
Time: Speakers:
13:30 Session Introduction
Chair: Jan Kosinski, Co-Chair: Matthias Preller
13:40 Integration of cellular functions by membrane transporters
Giulio Superti-Furga - CEMM, Austria
14:10 Modelling the interactions of bacterial Phosphatidylinositol-Specific Phospholipases C with host membranes
Natalie Reuter - University of Bergen, Norway

 

14:40 Science Slam for posters
15:40 Coffee Break

 

Session 2A: “The A and O in mechanisms of infections - probing interactions from the atom to organism scale;
Time: Speakers:
16:20 Session Introduction
Chair: Thomas Marlovits
16:30 Viewing the type III protein secretion injectisome at all resolutions scales
Jorge Galan - Yale University, USA
17:00 The Lassa virus glycoprotein: It takes a village
Erica Ollmann-Saphire - The Scripps Research Institute, USA

 

17:30 CSSB Building Tour
18:40 Poster Session - Networking Buffet

 

Day 2: November 14, 2017
Session 3A: “Taming increasingly larger and more complex beasts for understanding functions”
Time: Speakers:
9:00 Session Introduction
Chair: Michael Kolbe, Co-Chair: Dietmar Manstein
9:10 Structural and Molecular Biology of Type IV Secretion Systems
Gabriel Waksman - University College London, United Kingdom
9:40 Structures and dynamics of macromolecular motors revealed by electron cryomicroscopy and optical nanophotometry
Keiichi Namba - Osaka University, Japan

 

10:10 Coffee Break

 

Session 4A: “Extending the toolbox: Emerging technological advances and their combinations”
Time: Speakers:
10:40 Session Introduction
Chair: Kay Grünewald, Co-chair: Matthias Wilmanns
10:50 CryoEM: Challenges and Opportunities
Bridget Carragher - New York Structural Biology Center, USA
11:20 Macromolecular structure determination using X-ray FELs
Henry Chapman - DESY/Universität Hamburg, Germany

 

12:00 Meet the speakers lunch break

 

Session 1B: “Integrating and merging structural with complementary data across multiple scales and dimensions”
Time: Speakers:
13:30 High-resolution, integrative modelling of biomolecular complexes from fuzzy data
Alexandre Bonvin - Utrecht University, Netherlands
14:00 Molecular assembly and secretion mechanism of enteropathogenic E.coli type III secretion system
Biao Yuan - Rega Institute for Medical Research, Belgium
14:20 Insights into the cap-snatching mechanism of arena- and bunyaviruses
Sophia Reindl - Bernhard Nocht Institute for Tropical Medicine, Germany

 

14:40 Coffee Break

 

Session 2B: “The A and O in mechanisms of infections - probing interactions from the atom to organism scale”
Time: Speakers:
15:10 Marylyn Addo - University Medical Center Hamburg-Eppendorf, Germany
15:40 Understanding mycobacterial virulence, from A-canthamoeba to Z-ebrafish
Wilbert Bitter - VU University Medical Center, Netherlands
16:10 A genome-wide screen reveals genes with key roles in pre-erythrocytic development of the malaria parasite Plasmodium
Volker Heussler - Universität Bern, Switzerland
16:40 In situ architecture, function and evolution of a contractile injection system
Desirée Böck - ETH Zurich, Switzerland
17:00 Structure and dynamics of the mycobacterial type VII secretion system by single particle analysis
Luciano Ciccarelli - Institute of Molecular Biotechnology, Austria

 

17:20 A Different Perspective
Why some Messages Go Viral, and Most Do Not

Eugene Quinn, Urbanist
18:30 Coach transfers to dinner location
19:00 Conference Dinner: Parlament im Hamburger Rathaus

 

Day 3: November 15, 2017
Session 3B: “Taming increasingly larger and more complex beasts for understanding functions”
Time: Speakers:
8:30 Structure of the hexagonal surface layer on Caulobacter crescentus cells
Jan Löwe - MRC Laboratory of Molecular Biology, United Kingdom
9:00 Insights into RNA-driven virus assembly
Sarah Butcher - University of Helsinki, Finland
9:30 Structural Characterization and Pharmacological Mediated Folding of the Molecular Motor Myosin
Patrick Reinke - Medical School Hannover - Germany
9:50 A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy
Linda Franken - Heinrich Pette Institute/ CSSB, Germany

 

10:10 Poster Prize Award Ceremony
10:30 Coffee Break

 

Session 4B: “Extending the toolbox: Emerging technological advances and their combinations”
Time: Speakers:
11:00 Structural systems biology by cross-linking/mass spectrometry - emerging prospects
Juri Rappsilber - Technische Universität Berlin, Germany and University of Edinburgh, Scotland
11:30 Decoding Molecular Plasticity in the Dark Proteome
Edward Lemke - EMBL, Germany
12:00 Structural characterization of protein-lipid complexes involved in clathrin-mediated endocytosis
Johannes Heidemann - Heinrich Pette Institute, Germany
12:20 Fibril structure of amyloid-beta(1-42) by cryo-electron microscopy
Gunnar Schröder - Forschungszentrum Jülich, Germany

 

12:40 Panel Discussion: Quo vadis – Structural Infection Biology
13:40 Closing Remarks
13:45 Lunch and Finish